Fig. 6.
Collecting duct (CD)-specific overexpression of periostin decreases the survival of pcy mice. pcy (n = 9) and PostnCD pcy (n = 10) mice were given standard chow and water ad libitum and monitored regularly until a humane end point was reached (46, 48). A: Gehan-Breslow survival curves indicate that CD-specific overexpression of periostin significantly decreased the survival of pcy mice. B: scatterplot in which the open symbols represent the ages of pcy and PostnCD pcy mice at the time of death. Closed symbols indicate the means ± SE for each group of mice. *P < 0.05, compared with littermate age-matched pcy mice.