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Periostin stimulates changes in the actin cytoskeleton and αVβ3-integrin clustering in autosomal dominant polycystic kidney disease (ADPKD) cells. Cells were incubated in control (A, C) media or media containing periostin (B, D) for 1 h, and then stained with phalloidin (green) to visualize F-actin fibers (A, B) or αVβ3-integrin antibody to visualize the cellular location of the integrin (C, D). Arrows denote areas of integrin clustering. Scale bar: 5 µm.
