Fig. 6.

Inhibition of pressure-induced myogenic constriction in rat afferent arterioles by TMEM16A antagonist (7 vessels) (A). Time courses of change in normalized luminal diameter when afferent arterioles were exposed to a TMEM16A antagonist (T16Ainh-A01, 10 µM, 5 vessels) (B), TMEM16A agonist (Eact, 10 µM, 5 vessels) (C), and Eact after preincubation of T16Ainh-A01 (5 vessels) (D). All experiments in B, C, and D were performed at the perfusion pressure of 80 mmHg. Agonist and antagonist were administered to the perfusion bath at time = 0. The straight lines are regression lines. Analysis of variance of regression coefficients indicate that each group has different regression equations as shown in Table 1.