Table 2.
Univariate and multivariate Cox regression analyses of clinicopathologic characteristics associated with recurrence in The Cancer Genome Atlas samples
| Variable |
Univariate analysis |
Multivariate analysis |
||
| HR (95%CI) | P-value | HR (95%CI) | P-value | |
| Six-lncRNA risk score | 1.341 (1.110-1.620) | 0.002a | 1.270 (1.018-1.585) | 0.034a |
| TNM stage (IV/III/II/I) | 1.727 (1.441-2.070) | < 0.001a | 1.705 (1.393-2.089) | < 0.001a |
| Gender (male/female) | 0.982 (0.711-1.355) | 0.911 | - | - |
| Age (> 60/≤ 60) | 0.956 (0.707-1.294) | 0.773 | - | - |
| HBV (yes/no) | 0.804 (0.505-1.281) | 0.359 | - | - |
| HCV (yes/no) | 1.271 (0.798-2.207) | 0.313 | - | - |
| Alcohol consumption (yes/no) | 1.062 (0.769-1.467) | 0.717 | - | - |
| Liver cirrhosis (yes/no) | 1.271 (0.861-1.877) | 0.228 | - | - |
| Albumin (> 3.5/≤ 3.5 g/dL) | 0.968 (0.659-1.424) | 0.870 | - | - |
| Creatinine (≥ 1.1/< 1.1 mg/dA) | 0.739 (0.511-1.069) | 0.109 | - | - |
| AFP (> 20/≤ 20 ng/mL) | 1.380 (0.972-1.959) | 0.072 | ||
| Platelet (> 250/≤ 250 × 109/L) | 1.314 (0.932-1.854) | 0.119 | - | - |
| Race (Asian/White) | 1.270 (0.928-1.739) | 0.136 | - | - |
| BMI (≥ 24/< 24) | 0.860 (0.697-1.062) | 0.161 | - | - |
| Family history (yes/no) | 0.920 (0.655-1.292) | 0.630 | - | - |
| ECOG (> 0/0) | 1.858 (1.329-2.598) | < 0.001a | 1.486 (1.045-2.114) | 0.028a |
| TP53 mutation (yes/no) | 1.389 (1.004-1.922) | 0.047a | 1.326 (0.894-1.967) | 0.161 |
a
Statistically significant. AFP: Alpha-fetoprotein; BMI: Body mass index; ECOG: Eastern Cooperative Oncology Group; HR: Hazard ratio; HBV: Hepatitis B virus; HCV: Hepatitis C virus.