FIGURE 3.

Targeted magnetic glyconanoparticles (mGNP) specifically labeled NPC and the NPC migrated to astrocytomas. mGNP were fabricated with (A) antibodies that target NPC (Nilo) or (B) control antibodies (H56) and injected contralaterally to CT-2A astrocytoma on day 13 of tumor growth. Arrowheads indicate hypointense signal at the tumors as early as 1 day after NPC injection, while arrows indicate absence of hypointense signals. No control particles were detected at the tumor. (C) NPC (red) were labeled with the mGNP (light blue) and migrated to the tumor (green). (D) No control nanoparticle labeled cells were detected near the tumor. T, tumor, scale bar is 50 μm (Elvira et al., 2012). Reproduced via Plos One Creative Commons Attribution (CC BY) license.