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. 2019 Jan 11;12:995. doi: 10.3389/fnins.2018.00995

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Copyright © 2019 Mallett, Shuboni-Mulligan and Shapiro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Magnetic resonance imaging (MRI) of NPCs migrating to stroke (Guzman et al., 2008, reproduced with permission). The top panel (A) shows a representative MRI of animals injected with NPCs before and over 24 days after the induction of stroke. White arrows show the location of labeled cells, moving from the site of injection to the area of stroke, denoted with an asterisk (^∗). The bottom panel (B–D) shows the histology of animals 24 days after stroke. Cells labeled with BrdU (red, B) were observed migrating away from the site of injection and into the corpus callosum. To quantify the migration, the area adjacent to the injection site was analyzed by counting cells in a counting box (C). The graph shows significantly greater migration away from the injection site in animals that received a stroke than the sham controls. Reproduced with permission.