Table 2.
Exogenous neural progenitor cells in stroke.
| Citation | Rat breed | Cell type | SPIO | Cell origin | Injection type |
|---|---|---|---|---|---|
| (a) Mouse neural stem cells (mNSC) | |||||
| Hoehn et al., 2002 | Wistar | HT22 mNSC | Ferumoxtran-10, Sinerem® | Immortalized primary mouse hippocampal neural cells derived from parent HT4 cells | Intracranial – Corpus Callosum/Cortex border |
| Modo et al., 2004 | Sprague-Dawley | MHP36 mNSC | Gadolinium-Rhodamine Dextran (GRID) | Cell line isolated from hippocampal proliferative zone of fetal mice (H-2Kb-tsA58) | Intracranial -Striatum |
| Modo et al., 2009 | Sprague-Dawley | MHP36 mNSC | Gadolinium-Rhodamine Dextran (GRID) | Cell line isolated from hippocampal proliferative zone of fetal mice (H-2Kb-tsA58) | Intracranial -Striatum |
| Guzman et al., 2008 | Sprague-Dawley | C17.2 mNSC | Ferumoxides, Feridex®IV | Immortalized cell line established from neonatal mouse (CD1 × C57BL/6) cerebellum | Intracranial – Cortex |
| Obenaus et al., 2011 | Sprague -Dawley | C17.2 mNSC | Ferumoxides, Feridex®IV | Immortalized cell line established from neonatal mouse (CD1 × C57BL/6) cerebellum | Intracranial – Striatum or Intraventricular – Lateral Ventricle |
| (b) Rat neural stem cells (rNSC) | |||||
| Zhang et al., 2003 | Wistar | rNSC | MPIO, Bangs | Isolated rNSC from young adult rat brain (SVZ) | Intracistern -Cisterna Magna |
| Jiang et al., 2005 | Wistar | rNSC | MPIO, Bangs | Isolated rNSC from the lateral wall of the lateral ventricle of adult Wistar rat | Intracistern -Cisterna Magna |
| Li et al., 2006 | Wistar | rNSC | MPIO, Bangs | Isolated rNSC from the adult rat brain near the lateral ventricle | Intracistern -Cisterna Magna |
| Li et al., 2010 | Wistar | rNSC | Ferumoxides, Feridex®IV | Isolated rNSC from young adult rat brain (SVZ) | |
| Wen et al., 2014 | Sprague-Dawley | rNSC | Polymersomes PEI-PDDLA | Isolated rNSC from the new born rat brain near the lateral ventricle | Intracranial -Striatum |
| (c) Human neural stem Cells (hNSC) | |||||
| Daadi et al., 2009 | Sprague-Dawley | hNSC | Ferumoxides, Feridex®IV | H7 Human embryonic stem cell (WiCell) derived with supplemented media | Intracranial -Striatum |
| Daadi et al., 2013 | Sprague-Dawley | hNSC | Ferumoxides, Feridex®IV | H7 Human embryonic stem cell (WiCell) derived with supplemented media | Intracranial -Striatum |
| Song et al., 2009 | Sprague-Dawley | HB1.F3 hNSC | Ferumoxides, Feridex®IV | Immortalized hNSC established from human fetal brain (ventricular zone) | Intracranial – Striatum or Intravascular – IV |
| Ashwal et al., 2014 | Sprague-Dawley | HFB 2050 hNSC | Ferumoxides, Feridex®IV | Cell line isolated from the ventricular zone of a human fetal cadaver | Intraventricular – Lateral Ventricle |