Table 3.
Radioactivity distribution of 111In-Au@HSANP in CT-26 tumor/ascites mice at one, 24, 48, and 96 h post intravenous administration.
| Organs | Mice Received iv Administration of 111In-Au@HSANP | |||
|---|---|---|---|---|
| 1 h | 24 h | 48 h | 96 h | |
| Blood | 0.44 ± 0.08 | 0.12 ± 0.04 | 0.07 ± 0.01 | 0.09 ± 0.03 |
| Heart | 0.17 ± 0.05 | 0.10 ± 0.06 | 0.06 ± 0.05 | 0.08 ± 0.03 |
| Lung | 13.31 ± 6.49 | 1.68 ± 0.85 | 0.34 ± 0.25 | 0.49 ± 0.40 |
| Liver | 16.09 ± 3.27 | 19.22 ± 2.78 | 24.39 ± 2.03 | 19.06 ± 3.74 |
| Stomach | 0.17 ± 0.06 | 0.09 ± 0.02 | 0.08 ± 0.03 | 0.10 ± 0.02 |
| S.I. | 0.45 ± 0.18 | 0.23 ± 0.10 | 0.15 ± 0.08 | 0.25 ± 0.16 |
| L.I | 0.15 ± 0.04 | 0.19 ± 0.11 | 0.14 ± 0.07 | 0.22 ± 0.06 |
| Pancreas | 0.15 ± 0.04 | 0.11 ± 0.03 | 0.22 ± 0.16 | 0.16 ± 0.02 |
| Spleen | 40.47 ± 2.36 | 46.45 ± 7.73 | 45.08 ± 11.19 | 34.90 ± 8.50 |
| Kidneys | 3.55 ± 1.00 | 5.44 ± 0.88 | 4.28 ± 0.67 | 4.36 ± 0.79 |
| Muscle | 0.03 ± 0.01 | 0.03 ± 0.01 | 0.02 ± 0.01 | 0.03 ± 0.01 |
| Urine | 23.68 ± 25.19 | 51.59 ± 18.76 | 22.11 ± 10.96 | 16.19 ± 7.41 |
| Feces | 0.03 ± 0.03 | 2.80 ± 1.71 | 1.80 ± 1.58 | 7.55 ± 2.38 |
| Bladder | 0.16 ± 0.06 | 0.22 ± 0.14 | 0.09 ± 0.02 | 0.19 ± 0.09 |
| Bone | 0.14 ± 0.05 | 0.29 ± 0.18 | 0.28 ± 0.11 | 0.21 ± 0.05 |
| CT-26 tumor | 0.29 ± 0.10 | 0.33 ± 0.07 | 0.19 ± 0.05 | 0.21 ± 0.03 |
| Ascites | 0.28 ± 0.07 | 0.22 ± 0.10 | 0.13 ± 0.02 | 0.22 ± 0.09 |
| T/M ratio | 9.5 | 11.1 | 9.3 | 7.0 |
Each value is expressed as a percentage of injection dose per gram of organ (%ID/g). Each value represents mean ± SD (n = 4). S.I., small intestine; L.I., large intestine; and T/M ratio, tumor-to-muscle ratio.