Table 4.
Radioactivity distribution of 111In-Au@HSANP in CT-26 tumor/ascites mice at one, 24, 48, and 96 h post intraperitoneal administration.
| Organs | Mice Received ip Administration of 111In-Au@HSANP | |||
|---|---|---|---|---|
| 1 h | 24 h | 48 h | 96 h | |
| Blood | 0.17 ± 0.07 | 0.15 ± 0.08 | 0.10 ± 0.04 | 0.11 ± 0.05 |
| Heart | 0.06 ± 0.03 | 0.08 ± 0.01 | 0.06 ± 0.02 | 0.17 ± 0.07 |
| Lung | 0.29 ± 0.18 | 2.78 ± 1.59 | 2.62 ± 0.71 | 15.70 ± 7.48 |
| Liver | 0.42 ± 0.23 | 1.11 ± 0.44 | 1.25 ± 0.33 | 3.78 ± 1.59 |
| Stomach | 0.41 ± 0.14 | 0.31 ± 0.10 | 0.33 ± 0.06 | 0.20 ± 0.04 |
| S.I. | 0.38 ± 0.41 | 0.23 ± 0.08 | 0.21 ± 0.09 | 0.22 ± 0.11 |
| L.I | 0.29 ± 0.25 | 0.30 ± 0.21 | 0.24 ± 0.04 | 0.19 ± 0.07 |
| Pancreas | 0.70 ± 0.19 | 0.55 ± 0.21 | 0.42 ± 0.06 | 0.46 ± 0.16 |
| Spleen | 1.14 ± 0.36 | 2.33 ± 0.18 | 2.38 ± 0.35 | 8.76 ± 3.96 |
| Kidneys | 0.41 ± 0.06 | 3.20 ± 0.65 | 3.11 ± 0.45 | 2.44 ± 0.35 |
| Muscle | 0.09 ± 0.12 | 0.04 ± 0.02 | 0.03 ± 0.02 | 0.05 ± 0.03 |
| Urine | 9.53 ± 2.36 | 62.81 ± 21.07 | 25.47 ± 19.24 | 10.54 ± 2.42 |
| Feces | 0.21 ± 0.24 | 7.76 ± 5.84 | 1.13 ± 0.72 | 3.48 ± 4.49 |
| Bladder | 0.31 ± 0.23 | 0.22 ± 0.07 | 0.31 ± 0.18 | 0.18 ± 0.07 |
| Bone | 0.02 ± 0.01 | 0.12 ± 0.07 | 0.06 ± 0.03 | 0.23 ± 0.10 |
| CT-26 tumor | 7.77 ± 2.99 | 8.89 ± 2.53 | 3.40 ± 0.94 | 1.45 ± 0.48 |
| Ascites | 41.33 ± 12.64 | 22.36 ± 5.28 | 12.86 ± 1.53 | 9.64 ± 3.39 |
| T/M ratio | 89.4 | 217.4 | 128.8 | 28.3 |
Each value is expressed as a percentage of injection dose per gram of organ (%ID/g). Each value represents mean ± SD (n = 4). S.I., small intestine; L.I., large intestine; and T/M ratio, tumor-to-muscle ratio.