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. 2019 Jan 7;20(1):190. doi: 10.3390/ijms20010190
AGS Aicardi-Goutières Syndrome
AhR aryl hydrocarbon receptor
APC antigen presenting cells
BBB blood brain barrier
BM bone marrow
CNS central nervous system
CSF cerebrospinal fluid
CSF-1 colony-stimulating factor-1
DAMP damage-associated molecular pattern
DC dendritic cell
DDX DEAD-box helicase
EAE experimental autoimmune encephalomyelitis
GFP green fluorescence protein
HSVTK herpes simplex virus thymidine kinase
iDTR inducible diphtheria toxin receptor
IFN interferon
IFNAR interferon α receptor
iNOS inducible nitric oxide synthase
IRF interferon regulatory factor
ISG interferon-stimulated gene
JAK Janus kinase
LPS lipopolysaccharide
MIF macrophage migration inhibitory factor
MDM Monocyte-derived macrophages
MiDM Microglia-derived macrophages
MOG myelin oligodendrocyte glycoprotein
MRI magnetic resonance imaging
MS multiple sclerosis
NK cell natural killer cell
NMO neuromyelitis optica
OPC oligodendrocyte progenitor cells
OSC organotypic slice cultures
PAMP pathogen-associated molecular pattern
PET positron emission tomography
poly(I:C) polyinosinic:polycytidylic acid
PPMS primary-progressive multiple sclerosis
PRR pattern recognition receptor
RFP red fluorescence protein
RLH Retinoic acid inducible gene (RIG)-I like helicase
RRMS relapsing-remitting multiple sclerosis
Runx1 Runt-related transcription factor 1
SOCS suppressor of cytokine signaling
STAT signal transducer and activator of transcription
TGFα transforming growth factor α
Th cell T helper cell
TLR toll-like receptor
TNF tumor necrosis factor
TREM2 triggering receptor also expressed on myeloid cells-2
TRIF TIR domain containing adapter inducing interferon beta
TSPO translocator protein
USP ubiquitin specific protease
VEGF vascular endothelial growth factor
VLA-4 very late antigen-4
WT wildtype
YFP yellow fluorescence protein
YS yolk sac
HHS Vulnerability Disclosure