A summary of the evidence for pleiofunctionality in rRNA-related molecules supporting the hypothesis of a self-replicating ribosome. rRNA = ribosomal ribonucleic acid (only one rRNA is shown though there are three in the ribosome, the 5S, 16S, and 23S). crRNA = complementary strand of rRNA posited to exist to make possible rRNA replication in self-replicating ribosome. The crRNA would also act as a messenger RNA (mRNA), or act itself as a source of transcription to produce mRNAs (see Root-Bernstein and Root-Bernstein, 2016; 2017). tRNA = transfer ribonucleic acid. aa-synthetase = amino acyl synthetase, which loads amino acids onto tRNA. Ribo-protein = ribosomal proteins (see Table 3, Table 4, Table 5 and Table 6). Boxes summarize the data from Table 1, Table 2, Table 3, Table 4, Table 5, Table 6 and Table 7 and the related text.