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. 2019 Jan 2;20(1):140. doi: 10.3390/ijms20010140

Table 2.

Non-canonical functions of ribosomal RNA (rRNA) [82,83,84,85,86,87,88].

Non-Canonical rRNA Properties Molecules Involved Functions
Transcription regulation 5S rRNA acting on transcription factor for polymerase factor IIIA Inhibits activation of RNA polymerase III-dependent transcription and related genes
Translation regulation Ribosomal protein fragments siRNA and RNAi inhibiting mRNA translation
Permits read-through of termination codons 23S rRNA fragment Inhibits release factor 2 (RF2)-dependent translation termination
Protein activity control 5S rRNA-RPL5-RPL11 complex Inhibits the Hdm2 protein which in turn regulates p53
Sources of novel transcripts 5.8S and 28S rRNA fragments Translated into proteins