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. 2018 Dec 24;20(1):72. doi: 10.3390/ijms20010072

Figure 4.

Figure 4

MLN4924 activated ER stress-related apoptosis in human chondrosarcoma cells. The jj012 and sw-1353 cells were treated with various concentrations of MLN4924 (250, 500, and 750 nM) and DMSO (for the control group) for 48 h. After they were harvested, cell lysates were analyzed by a Western blot analysis that used specific antibodies to molecules related to ER stress-induced apoptosis, including (a) c-Jun N-terminal kinase (JNK) and phospho-JNK, (b) GRP78, CHOP, and caspase-4. The results are representative of at least three independent experiments.