Figure 4.

Nampt expression in the bowel. (A) B-Nampt in small bowel; (B) B-Nampt in large bowel; (C) B-Nampt in paired samples from the same patient; (D) B-Nampt in large bowel: comparison with normal tissues derived from patients with polyps or colorectal adenocarcinomas. B-Nampt, Nampt expression in the bowel; NRQ, normalized relative quantities (fold change against geometric mean across all investigated samples); norm_P, samples of macroscopically normal colonic tissue obtained from patients with polyps during endoscopy; norm_T, samples of macroscopically normal colonic tissue (resection margins) obtained from patients with colorectal adenocarinomas during curative resection of tumors; q, quiescent; i, inflamed; i/q, ratio of expression in inflamed to quiescent tissue; nP, normal tissue derived from patients with polyps; nT, normal tissue derived from patients with tumors; i/nP, ratio of expression in inflamed to normal tissue from patients with polyps; i/nT, ratio of expression in inflamed to normal tissue from patients with tumors; q/nP, ratio of expression in quiescent to normal tissue from patients with polyps; q/nT, ratio of expression in quiescent to normal tissue from patients with tumors. Data are presented as geometric means with 95% confidence interval (CI) and analyzed using t-test for unpaired samples (panels A and B) or t-test for paired samples (panel C) or as medians with 95%CI and analyzed with Kruskal–Wallis H test (panel D). a, significantly different from norm_P; b, significantly different from norm_T; c, significantly different from inflamed; d, significantly different from quiescent.