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. 2018 Dec 22;24(1):43. doi: 10.3390/molecules24010043

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Ring-opening reactions catalyzed by (A) macrolide esterases [73] and (B) fosfomycin-resistance enzymes FosX/A/B [77]. The hydrolysis sites on the antibiotics are marked by red arrows.