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Pharmacological effect of compound 2 in an experimental model of cutaneous leishmaniasis. BALB/c mice were infected with 106 L. amazonensis promastigotes in the stationary growth phase and lesion development was monitored for four weeks. Lesion size is expressed as mean ± SD of eight animals per group during the treatment by oral (A) or topical (B) route. * p < 0.05 (two-way ANOVA, followed by Bonferroni’s multiple comparison test).
