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. 2019 Jan 4;20(1):163. doi: 10.3390/ijms20010163

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Treatment of BC cells lacking RSU-1 with human GDF-15 protein reverses the effect of RSU-1 silencing on the mRNA expression of actin-related genes RhoA, Rho associated kinase-1 (ROCK-1), and Fascin-1, as well as MMP-2. Relative mRNA expression of Rac (a), RhoA (b), Cdc42 (c), ROCK-1 (d), Fascin-1, (e) and MMP-2 (f) in MCF-7 and MDA-MB-231 cells transfected with NSC or RSU-1 siRNA with or without 24 h treatment with human GDF-15 (10 ng/mL). Four (4) independent real-time PCR experiments were performed, and data were analyzed using the ΔΔCt method and having NSC-treated cells as calibrators. Asterisks denote statistically significant changes (p-value < 0.05).