Figure 1.

Effects of shikonin (SHK) on acetaminophen (APAP)-induced liver injury. (A) The chemical structure of SHK. (B) Representative histological images of hematoxylin and eosin (H&E) staining of liver tissues obtained in different groups. (C,D) Mice were administered SHK i.p. for 1 h, and then injected with APAP for 9 h. Then, the serum levels of serum alanine/aspartate aminotransferases (ALT and AST) were measured. All of the data shown represent the average from five independent experiments. * p < 0.05 versus the control group; # p < 0.05 and ## p < 0.01 versus the APAP group.