DILI | Drug-induced liver injury |
APAP | Acetaminophen |
SHK | Shikonin |
ALT/AST | Alanine/aspartate aminotransferase |
GSH | Glutathione |
ROS | Reactive oxygen species |
MPO | Myeloperoxidase |
GSK3β | Glycogen synthase kinase-3β |
Akt | Protein Kinase B |
Nrf2 | Nuclear factor erythroid 2-related factor 2 |
HO-1 | Heme oxygenase 1 |
DCFH-DA | 2′,7′-Dichlorofluorescin diacetate |
LiCl | Lithium chloride |
MTT | 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide |