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. 2018 Dec 23;20(1):51. doi: 10.3390/ijms20010051

Figure 2.

Figure 2

Ubiquitination of HDAC3 leads to decreased expression of HDAC3. (A) In anti-cancer drug-sensitive cancer cells, miR-335 binds to 3′-UTR of Seven in Absentia Homolog 2 (SIAH2) (E3 ubiquitin ligase) to decrease expression of SIAH2. However, SIAH2 does not bind to HDAC3. HDAC3 confers sensitivity to anti-cancer drugs. (B) In anti-cancer drug-resistant cancer cells, SIAH2 binds to HDAC3 and causes ubiquitination of HDAC3. The lack of HDAC3 confers resistance to anti-cancer drugs. The↑arrows denotes increased expression level and ↓arrows denotes decreased expression level.