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. 2019 Jan 2;24(1):153. doi: 10.3390/molecules24010153

Figure 4.

Figure 4

Effect of 4-AN on kinase activity. (A) Inhibitory activities of 4-AN against a short panel of disease-related protein kinases. The table displays the remaining kinase activities detected after treatment with 2 or 20 µM of 4-AN. Candida equivalents of the tested protein kinases were derived from the Candida Genome Database (http://www.candidagenome.org/) and ProViz tool (http://proviz.ucd.ie/), UI—Candida equivalent unidentified. Results are expressed in % of maximal activity, i.e., measured in the absence of inhibitor but with an equivalent dose of DMSO (solvent of the tested compounds). ATP concentration used in the kinase assays was 15 µmol/L (values are means, n = 2). Kinases are from human origin unless specified: Rn, Rattus norvegicus; Mm, Mus musculus; Pf, Plasmodium falciparum; Lm, Leishmania major; Ssc, Sus scrofa domesticus; Ld, Leishmania donovani. (B) Docked binding modes for 4-AN in the ATP-binding pocket of YAK1 (left) and DYRK1A (right).