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Human EXO1 participates in both replicative and post-replicative processes. In the replicative process, EXO1 contributes to DNA replication by assisting in the removal of mismatches, bypassing the lesion using translesion synthesis, or by assisting with nucleotide excision repair by activating the NER repair pathway. EXO1 also has a role in DNA resection during the process of homologous recombination.
