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. 2018 Dec 21;20(1):40. doi: 10.3390/ijms20010040

Figure 9.

Figure 9

EF-G GTPase activity and translocation. The tRNA pe/E and ap/A (or ap/ap) hybrid states are observed. The 16S rRNA nucleotides 930–1380 are black (head/beak domain). mRNA (red) occupies the channel between the 16S rRNA body and head/beak (the neck). The codon-anticodon latch is not fully closed and the ap/A tRNA anticodon stem loop (ASL) has disengaged from the latch and has begun to translocate toward the P-site. For the ap/A-site tRNA, the 3′-CCA, where a peptide chain would be attached, makes a typical CCA A-site contact (C75:G2553). The pe/E tRNA 3′-CCA makes a typical E-site contact (U2431, A2432). EF-G·GDP is in an extended conformation supporting forward translocation and acting as a pawl to prevent reverse translocation.