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. 2019 Jan 6;24(1):187. doi: 10.3390/molecules24010187

Figure 5.

Figure 5

Compound 1 enhances insulin sensitivity in 3T3-L1 adipocytes through activating AMPK-p38 pathway. (A) Cell viability of mature 3T3-L1 adipocytes when treated with different concentrations of compound 1 for 24 h. (B) Compound 1 promotes insulin-stimulated glucose uptake in 3T3-L1 adipocytes. (C) Compound 1 activates the proteins in insulin signaling pathway, including IRS-1, Akt and GSK-3β. (D) Compound 1 increases the phosphorylation of AMPK and p38MAPK. Data are shown as mean ± SD, n = 6. # p < 0.05, ## p < 0.01, vehicle vs. insulin. * p < 0.05, ** p < 0.01, compound 1 vs. DMSO.