Table 2.
Formulation | Preparation a | Concentration (mg/mL) | D10 (nm) | D50 (nm) | D90 (nm) |
---|---|---|---|---|---|
NS-PA-L | freeze drying | 6 | 274 | 397 | 558 |
NS-PB-L | freeze drying | 6 | 472 | 836 | 1395 |
NS-PC-L | freeze drying | 6 | 598 | 1156 | 2262 |
NS-PB-S | concentrating, freeze drying | 30 | 448 | 806 | 1612 |
NS-PC-S | concentrating, freeze drying | 30 | 618 | 1225 | 2466 |
NS-Hα-1 | none | 30 | 624 | 1211 | 2701 |
NS-Hα-2 | adding 0.15% PEG 4000 | 30 | 627 | 1144 | 2402 |
a adjusting pH and osmotic pressure were conducted for each formulation.