Table 3.
Formulation | Tmax (0–72 h) (h) | Cmax (0–72 h) (ng/mL) | AUC0→t (µg·h/mL) | t1/2 (h) |
---|---|---|---|---|
Oral | 4.9 ± 0.8 | 48.6 ± 12.1 d | 0.6 ± 0.2 d | 11.0 ± 1.9 d |
NS-PA-L | 14.5 ± 0.0 | 1104.7 ± 162.5 a | 192.3 ± 21.8 a | 170.5 ± 16.7 a |
NS-PB-L | 14.5 ± 0.0 | 518.9 ± 109.7 a,†,b | 153.2 ± 20.2 a,b | 222.0 ± 23.3 a,b |
NS-PC-L | 14.5 ± 0.0 | 685.5 ± 60.9 †,c | 163.0 ± 29.7 c | 406.8 ± 34.2 b |
NS-PB-S | 7.0 ± 2.0 | 189.4 ± 32.5 b | 98.5 ± 21.2 b | 208.8 ± 17.4 † |
NS-PC-S | 9.0 ± 2.0 | 232.9 ± 122.2 c | 110.2 ± 32.1 c | 266.9 ± 44.4 † |
NS-Hα-1 | 6.0 ± 0.0 | 218.5 ± 31.9 | 113.1 ± 14.5 | 241.5 ± 39.2 |
NS-Hα-2 | 7.0 ± 2.0 | 209.7 ± 24.2 d | 96.9 ± 9.8 d | 252.3 ± 48.8 d |
†p < 0.1, a,b,c,d p < 0.05.