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. 2018 Dec 26;24(1):80. doi: 10.3390/molecules24010080

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of gigantol on protein expression related to apoptosis in MES-13 cells under high glucose conditions. Cells were pretreated with different concentrations of gigantol (1, 5, 10 or 20 μmol/L) for 1 h and then exposed to normal (NG) or high (HG) glucose for an additional 48 h. (A): The photographs are representative western blots for cleaved caspase-9 and cleaved caspase-3. The quantitative cleaved caspase-9 and cleaved caspase-3 expression levels are listed in the lower pannel. (B): The densities of protein bands for Bax or Bcl-2 were quantitated and the ratio of Bax to Bcl-2 was calculated. The experiments were performed in triplicate and data are presented as the mean ± SD of five independent experiments (n = 5). ^a p < 0.05 and ^b p < 0.01 when compared to the normal glucose vehicle (Veh)-treated control group. ^c p < 0.05 and ^d p < 0.01 when compared to the high glucose vehicle-treated group.

Effects of gigantol on protein expression related to apoptosis in MES-13 cells under high glucose conditions. Cells were pretreated with different concentrations of gigantol (1, 5, 10 or 20 μmol/L) for 1 h and then exposed to normal (NG) or high (HG) glucose for an additional 48 h. (A): The photographs are representative western blots for cleaved caspase-9 and cleaved caspase-3. The quantitative cleaved caspase-9 and cleaved caspase-3 expression levels are listed in the lower pannel. (B): The densities of protein bands for Bax or Bcl-2 were quantitated and the ratio of Bax to Bcl-2 was calculated. The experiments were performed in triplicate and data are presented as the mean ± SD of five independent experiments (n = 5). ^a p < 0.05 and ^b p < 0.01 when compared to the normal glucose vehicle (Veh)-treated control group. ^c p < 0.05 and ^d p < 0.01 when compared to the high glucose vehicle-treated group.