Figure 5.

Knockdown of distinct peptide precursor proteins significantly affects heart function in intact Drosophila larvae. Depicted are the individual effects of peptide precursor protein knockdown on (A) heart rate and (B) rhythmicity. daughterless-Gal4 (da-Gal4) was used as a ubiquitous driver. Data are presented as mean values (± S.E.M.) of the relative changes in the respective parameters in relation to the depicted controls. At least ten animals per genotype were measured. Significance levels are indicated by asterisks (Student´s t-test, * p < 0.05; ** p < 0.01; *** p < 0.001).