Table 1.
Peptides used in this study and corresponding effects on distinct heart parameters in semi-intact larvae.
| Peptide | Sequence | Heart Rate | Diastolic Interval | Systolic Interval | Fractional Shortening | Arrhythmicity Index |
|---|---|---|---|---|---|---|
| AKH | QLTFSPDWa | / | / | / | / | / |
| AstA1 | VERYAFGLa | / | / | / | + | / |
| AstA2 | LPVYNFGLa | / | - | + | / | / |
| AstA3 | SRPYSFGLa | / | / | / | / | / |
| AstA4 | TTRPQPFNFGLa | Θ | Θ | Θ | Θ | Θ |
| Corazonin | QTFQYSRGWTNa | ++ | -- | + | / | / |
| DH31 | TVDFGLARGYSGTQEAKHRMGLAAANFAGGPa | +++ | - | -- | / | / |
| DSK1 | FDDYGHMRFa | / | / | / | / | / |
| DSK2 | GGDDQFDDYGHMRFa | / | / | / | / | / |
| Leucokinin | NSVVLGKKQRFHSWGa | / | / | / | + | / |
| Proctolin | RYLPT | +++ | --- | / | / | + |
| sNPF11-11 | AQRSPSLRLRFa | / | / | / | / | / |
| sNPF14-11 sNPF212-19 | SPSLRLRFa | / | / | / | / | / |
| Tachykinin 1 | APTSSFIGMRa | +++ | -- | / | / | + |
| Tachykinin 2 | APLAFVGLRa | / | / | / | / | / |
| Tachykinin 3 | APTGFTGMRa | + | / | / | / | / |
| Tachykinin 4 | APVNSFVGMRa | / | / | / | / | ++ |
| Tachykinin 5 | APNGFLGMRa | +++ | -- | / | / | / |
| Tachykinin 6 | AALSDSYDLRGKQQRFADFNSKFVAVRa | / | / | / | / | / |
Listed are all peptides applied in this study along with their respective sequence and the effects on individual heart parameters (at 1 × 10−7 M). Nomenclature indicates significance of the observed effects (+ = increase, p < 0.05; ++ = increase, p < 0.01; +++ = increase, p < 0.001; - = decrease, p < 0.05; -- = decrease, p < 0.01; --- = decrease, p < 0.001; / = no significant effect; paired sample Student´s t-test). Θ indicates full arrest of heartbeat upon peptide application.