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If modulation in CMPCs expressing HCN4-GFP. (A) Effects of 10 nM Isoproterenol on voltage dependency of If activation. (B) Effects of 1 mM 8-Br-cAMP on voltage dependency of If activation and speed of If activation at −120 mV. (C) typical If traces at –120 mV in the absence and presence of 8-Br-cAMP. * indicates P < 0.05.
