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. 2019 Jan 1;24(1):142. doi: 10.3390/molecules24010142

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The role of dihydrofolate reductase (DHFR) and pteridine reductase 1 (PTR1) in trypanosome folate and pterin metabolism. Trypanosomes, which are auxotrophic for folates and pterins, salvage them from the host. The structures of folate and biopterin are shown (A). Folates and pterins are taken up by transporters (the folate-biopterin transporter superfamily includes biopterin transporter 1 (BT1) and folate transporter 1 (FT1)) after which they are reduced to their functional cofactors (B).