Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 8;20(1):210. doi: 10.3390/ijms20010210

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

EI24 (etoposide-induced protein 2.4 homolog) is the main connection between ubiquitin-mediated proteasomal system (UPS) and autophagy. The concerted action of ubiquitin ligases E1-E3 results in ubiquitination of target proteins to label for UPS-mediated degradation. Ubiquitin chain transfer to target proteins is catalyzed by the RING-domain E3 ligases. EI24, an autophagy-inducing protein, can cause autophagy-mediated degradation of RING-domain E3 ligases. Thick arrows represent main pathways, thin arrows—side pathways.