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. 2018 Dec 20;20(1):4. doi: 10.3390/ijms20010004

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The two volcano plots are the graphical representation of the quantitative comparison performed in the present study. Each dot represents a protein; in blue unchanged proteins and in yellow (−log10 p value > 1.3) and green (−log10 p value > 2) the ones significantly dysregulated in each analysis. The first volcano plot shows the ALS vs control comparison and the second one shows the FTLD-U vs. control comparison. The Bar plot describes the number of significantly dysregulated proteins (up-regulated: red. Down-regulated: green). The Venn diagram illustrates the number of significantly dysregulated proteins in each disease and the observed overlap across comparisons.