. 2018 Dec 27;20(1):97. doi: 10.3390/ijms20010097

Table 3.

Associations of SNPs in DNA repair genes with the risk of CRC and its major sub-sites (colon/rectum).

			All CRC Patients				Colon Cancer Patients				Rectal Cancer Patients
Gene	Genotype	Controls ^a	Cases ^a	OR ^b	95% CI	p-Value	Cases ^a	OR ^b	95% CI	p-Value	Cases ^a	OR ^b	95% CI	p-Value	HWE ^c
SNP	Genotype	Controls ^a	Cases ^a	OR ^b	95% CI	p-Value	Cases ^a	OR ^b	95% CI	p-Value	Cases ^a	OR ^b	95% CI	p-Value	Χ², p-Value
Czech Republic
EME1 rs12450550	TT	678	815	Ref			526	Ref			284	Ref			1.07, 0.58
	TC	410	570	1.19	1.00–1.40	0.05	363	1.17	0.97–1.40	0.11	198	1.20	0.96–1.50	0.11
	CC	73	108	1.24	0.90–1.70	0.20	64	1.15	0.80–1.65	0.46	41	1.38	0.91–2.09	0.13
	TC+CC	483	678	1.19	1.02–1.40	0.03	427	1.16	0.97–1.39	0.10	239	1.23	0.99–1.52	0.06
	TT+TC	1088	1385	Ref			889	Ref			482	Ref
	CC	73	108	1.16	0.84–1.59	0.36	64	1.08	0.76–1.55	0.66	41	1.28	0.86–1.93	0.23
REV3L rs3204953	GG	839	1049	Ref			666	Ref			371	Ref			4.68, 0.10
	GA	304	405	1.09	0.91–1.30	0.37	261	1.12	0.91–1.37	0.27	139	1.06	0.83–1.34	0.66
	AA	15	43	2.32	1.27–4.25	0.006 *	30	2.59	1.36–4.91	0.004 *	13	1.97	0.92–4.22	0.08
	GA+AA	319	448	1.14	0.96–1.36	0.13	291	1.19	0.98–1.44	0.08	152	1.10	0.87–1.39	0.42
	GG+GA	1143	1454	Ref			927	Ref			510	Ref
	AA	15	43	2.28	1.24–4.17	0.008 *	30	2.52	1.33–4.77	0.005 *	13	1.95	0.91–4.18	0.09
Austria
POLQ rs1381057	CC	372	413	Ref			267	Ref			134	Ref			1.49, 0.47
	CT	349	423	1.09	0.90–1.34	0.38	250	1.00	0.80–1.25	1.00	166	1.32	1.01–1.74	0.04
	TT	99	114	1.05	0.77–1.42	0.76	65	0.93	0.65–1.32	0.68	49	1.40	0.94–2.08	0.10
	CT+TT	448	537	1.08	0.90–1.31	0.40	315	0.98	0.80–1.22	0.89	215	1.34	1.04–1.74	0.03
	CC+CT	721	836	Ref			517	Ref			300	Ref
	TT	99	114	1.00	0.75–1.34	0.98	65	0.93	0.66–1.29	0.66	49	1.21	0.84–1.75	0.32
REV1 rs3087399	AA	593	673	Ref			414	Ref			243	Ref			0.02, 0.99
	AG	208	259	1.10	0.89–1.36	0.39	151	1.04	0.81–1.32	0.78	105	1.25	0.95–1.66	0.11
	GG	19	18	0.83	0.43–1.60	0.58	17	1.27	0.65–2.48	0.48	1	0.13	0.02–0.96	0.05
	AG+GG	227	277	1.08	0.87–1.32	0.50	168	1.06	0.83–1.34	0.65	106	1.16	0.88–1.53	0.30
	AA+AG	801	932	Ref			565	Ref			348	Ref
	GG	19	18	0.81	0.42–1.56	0.53	17	1.26	0.65–2.44	0.50	1	0.12	0.02–090	0.04

OR—odds ratio; CI—confidence interval. Nominally significant results are in bold. Results that passed the Benjamini–Hochberg test for multiple comparisons are marked with an asterisk. ^a Numbers may not add up to 100% of subjects due to genotyping failure. All of the samples that did not give a reliable result in the first round of genotyping were retested in up to two additional rounds. Samples failing these procedures were omitted from the analysis. ^b Logistic regression analysis values are adjusted for age. ^c X² and p-values for the deviation of the observed and of the numbers expected from the Hardy–Weinberg equilibrium (HWE) in the controls.