. 2018 Dec 27;20(1):97. doi: 10.3390/ijms20010097

Table 4.

Clinical characteristics significantly affecting overall survival (OS) and event free survival (EFS) in CRC patients with complete follow up.

		Czech Republic					Austria
Variables		N ^a	OS		EFS		N ^a	OS		EFS
Variables		N ^a	HR (95% CI)	p-Value	HR (95% CI)	p-Value	N ^a	HR (95% CI)	p-Value	HR (95% CI)	p-Value
Sex	Female	696	Ref		Ref		389	Ref		Ref
Sex	Male	1133	1.47 (1.20–1.80)	0.0002	1.29 (1.09–1.52)	0.003	561	1.37 (1.03–1.83)	0.03	1.43 (1.11–1.83)	0.005
Age (years)	<50	149	Ref		Ref		129	Ref		Ref
	(50, 60]	433	0.96 (0.62–1.50)	0.87	1.06 (0.76–1.49)	0.72	208	1.44 (0.77–2.69)	0.26	1.62 (0.99–2.65)	0.05
	(60, 70]	639	1.08 (0.71–1.65)	0.72	0.90 (0.65–1.25)	0.54	323	2.14 (1.21–3.79)	0.01	1.68 (1.05–2.68)	0.03
	>70	610	1.47 (0.97–2.24)	0.07	1.05 (0.76–1.46)	0.77	291	3.11 (1.77–5.47)	<0.0001	2.53 (1.60–4.00)	<0.0001
BMI	(18.5, 25]	434	Ref		Ref		296	Ref		Ref
	<18.5	456	0.99 (0.77–1.27)	0.92	1.06 (0.86–1.32)	0.58	17	1.12 (0.41–3.07)	0.83	1.31 (0.57–3.00)	0.52
	(25, 30]	626	0.83 (066–1.06)	0.13	0.94 (0.77–1.15)	0.54	336	0.79 (0.55–1.12)	0.18	0.85 (0.63–1.15)	0.29
	>30	315	0.58 (0.43–0.80)	0.0008	0.83 (0.65–1.06)	0.13	181	1.13 (0.77–1.65)	0.54	1.04 (0.74–1.46)	0.83
Smoking habit	No	967	Ref		Ref		251	Ref		Ref
Smoking habit	Yes ^b	777	1.266 (1.049–1.529)	0.01	1.27 (1.08–1.48)	0.003	263	0.93 (0.65–1.32)	0.67	1.02 (0.75–1.39)	0.91
Stage	I	277	Ref		Ref		188	Ref		Ref
	II	498	1.75 (1.10–2.80)	0.02	1.99 (1.41–2.82)	0.0001	227	1.00 (0.57–1.76)	1.00	0.90 (0.56–1.45)	0.67
	III	491	3.46 (2.22–5.39)	<0.0001	3.45 (2.47–4.83)	<0.0001	354	1.51 (0.92–2.45)	0.10	1.55 (1.03–2.32)	0.03
	IV	384	8.91 (5.78–13.74)	<0.0001	6.00 (4.30–8.38)	<0.0001	120	7.98 (4.95–12.88)	<0.0001	9.33 (6.21–14.02)	<0.0001
5FU-based chemotherapy	No	765	Ref		Ref		389	Ref		Ref
5FU-based chemotherapy	Yes	797	1.022 (0.84–1.24)	0.82	1.387 (1.18–1.63)	<0.0001	515	1.33 (0.99–1.78)	0.06	1.79 (1.38–2.32)	<0.0001

HR—hazard ratio; CI—confidence interval; BMI—body mass index. Significant results are in bold. ^a Numbers may not add up to 100% of the available subjects because of missing information. ^b Ex-smokers included in smokers.