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Experimental plan of gamma radiation exposure of in vitro lung vascular networks (flow-adapted endothelial cells) and LGM2605 treatment. FAECs were exposed to 0 Gy, 0.25 Gy, 0.5 Gy, or 1 Gy gamma radiation and treated with 0 µM, 50 µM, or 100 µM LGM2605 30 min following radiation exposure. Cells were harvested 24 h post radiation exposure and evaluated for inflammation, inflammasome activation, and gene expression changes related to profibrogenic and antioxidant processes.
