Figure 2.

Motor deficits are decreased in BACHD/GFAP-CreER^T2-tam mice. Rotarod analysis of a cohort of BACHD (B), BACHD/GFAP-CreER^T2-tam (BG) and wild-type (WT) mice at 2, 6 and 12 months of age. There is a decreased latency to fall from the rotarod beginning at 2 months of age in BACHD mice. (A) Latency to fall in BACHD/GFAP-CreER^T2-tam mice is increased at 6 and 12 months when all mice are grouped together, BACHD (n = 33), wild type (n = 32), BACHD/GFAP-CreER^T2-tam (n = 40). This change is observed in male (B) and female (C) BACHD/GFAP-CreER^T2-tam mice. An additional GFAP-CreER^T2 (N-GFAP-CreER^T2) mouse was bred to confirm that the original findings were not due to the specific Cre mouse chosen (D–F). The latency to fall of the new BACHD/N-GFAP-CreER^T2-tam (BG-N) mice is reduced for the mice as a group at 6 and 12 months, BACHD (n = 12), wild type (n = 11), BACHD/N-GFAP-CreER^T2 -tam (n = 10); the robust observed difference in male mice likely drives this result. All data are log-transformed and presented as mean ± SEM. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001.