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. 2018 Oct 12;28(3):487–500. doi: 10.1093/hmg/ddy363

Figure 3.

Figure 3

Psychiatric-like deficits in BACHD/GFAP-CreERT2-tam mice. The light–dark box test was used to assess anxiety-like behaviors at 2, 6 and 12 months of age. As a group, there is a significant difference in performance at 2 and 12 months of age between BACHD and wild type. BACHD (n = 21), BACHD/GFAP-CreERT2-tam (n = 24) and wild type (n = 32). As a group, BACHD/GFAP-CreERT2-tam mice also have reduced performance when compared to wild type at 2 and 12 months. The difference in performance is observed primarily in females. (D–F) The forced swim test was used to analyze depressive-like phenotypes in the mice; BACHD (n = 32), BACHD-GFAP-CreERT2-tam (n = 40) and wild type (n = 27). As a group, BACHD and BACHD/GFAP-CreERT2 mice have increased immobility at 2 months as compared to wild-type mice. (D) By 12 months of age, the BACHD/GFAP-CreERT2 mice are more mobile than BACHD mice. The decrease in immobility is due to changes in BACHD-GFAP-CreERT2-tam male mice at 6 and 12 months (E) and not female BACHD-GFAP-CreERT2-tam mice (F). Data are mean ± SEM. *P < 0.05, **P < 0.01.