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. 2018 Oct 12;28(3):487–500. doi: 10.1093/hmg/ddy363

Figure 5.

Figure 5

Striatal post-synaptic protein expression in BACHD/GFAP-CreERT2-tam mice. Post-synaptic protein expression level of α-actn2 is decreased in the striatum of BACHD mice at 13- to 14-month-old mice. Immunofluorescence staining of α-actn2 (A) wild-type (n = 4), (B) BACHD/GFAP-CreERT2 (n = 5) and (C) BACHD (n = 5) mice stained with α-actn2 antibody reveals a decrease in BACHD mice, arrows indicate striatal staining in all panels. Immunofluorescence staining with PSD-95 in (D) wild-type, (E) BACHD/GFAP-CreERT2 and (F) BACHD mice also reveals a decrease in BACHD striatum. (G, H) Charts detailing the reduction of α-actn2 and PSD-95 in BACHD mice and increased expression in BACHD/GFAP-CreERT2 mice striata. ***P < 0.0001. Data are mean ± SEM. One-way ANOVA and Tukey’s HSD post hoc test were used for analysis.