Table 2.

Characteristics of Included Studies

Year	Author	Country	Design	Setting	N Enrolled	N Completed	Duration of therapy
2013	Alam	Bangladesh	Double-Blind RCT	University Single-Center	74	65	6 weeks
2016	Cash	USA	Double-Blind RCT	Multicenter	72	70	4 weeks
2005	Capanni	Italy	Double-Blind RCT	University Single-Center	178	173	12 weeks
2007	Cappello	Italy	Double-Blind RCT	University Single-Center	57	50	4 weeks
1989	Carling	Sweden	Double-blind Cross Over 3-arm RCT 1-Week Washout	2 University Centers	40	38	2 weeks
1984	Dew	Wales	Double-Blind Cross Over Washout Period	Multicenter	29	29	2 weeks
1988	Lech	Dutch	Double-Blind RCT	University Single-Center	47	42	4 weeks
1997	Liu	China	Double-Blind RCT	University Single-Center	110	101	4 weeks
2009	Merat	Iran	Double-blind RCT	University Single- Center	90	60	8 weeks
1979	Rees	UK	Double-Blind Cross Over Washout Period Defined by Recurrence of Active Symptoms	University Single- Center	18	16	3 weeks
1990	Schneider	USA	Double-blind Cross Over RCT 2-Week Washout	University Single- Center	60	47	6 weeks
1988	Weiss	Germany	Single blinded, RCT	Hospital, single center	60	46	3 weeks