Table 2.

Integrins expressed on leukocytes and tumor cells and their ligands

Adhesion molecule	Family	Leukocyte subtype	Ligand	Expression on tumor cells
VLA-4 (α4ß1) (CD49d)	Integrin	Monocytes Neutrophils in case of sepsis	VCAM-1 MAdCAM-1 JAM-B	Melanoma, osteosarcoma, kidney carcinoma, leukemia, oral squamous cell carcinoma, ovarian cancer
LFA-1 (αLß2) (CD11a/CD18)	Integrin	Neutrophils Monocytes	ICAM-1 ICAM-2 JAM-A
Gp150,95 (CD11c/CD18)	Integrin	Monocytes Macrophages Granulocytes Langerhans cells	iC3b JAM-C
α4ß7 (CD49d/ß7)	Integrin	Lymphocytes (mucosal lymphoid nodules)	MAdCAM-1
αMß2 (mac-1) (CD11b/CD18)	Integrin	Monocytes Macrophages Granulocytes Langerhans cells	iC3b ICAM-1 ICAM-2 JAM-C
αDß2	Integrin	Macrophages ?	ICAM-3
CD47		T cell	VCAM-1 ICAM-1
ICAM-1	Ig superfamily	Monocytes Epithelial cells Fibroblasts	LFA-1 (leukocytes) Mac-1 (leukocytes)*	Breast cancer, melanoma, oral squamous carcinoma, esophageal squamous carcinoma, papillary thyroid carcinoma, salivary adenoid cystic carcinoma, gastric cancer, non-small-cell lung cancer, osteosarcoma, prostate cancer
ICAM-2 ICAM-3	Ig superfamily	Endothelial cells Leukocytes Langerhans cells	LFA-1 (CD11a)
VCAM-1	Ig superfamily	Activated endothelial cells	VLA-4
PECAM-1	Ig superfamily	Endothelial cells Monocytes Neutrophils	PECAM-1 (CD31)
MAdCAM-1	Ig superfamily	Endothelial cells	L-selectin α4ß7
L1-CAM	Ig superfamily	Tumor cells	L1-CAM α5ß1 αVß3 (endothelium)	Colorectal carcinoma, epithelial ovarian carcinoma, renal cell carcinoma, melanoma, pancreatic ductal adenocarcinoma, breast cancer
αVß3	Integrin	Tumor cells	L1-CAM	Prostate cancer, melanoma
α5ß1	Integrin	Tumor cells	L1-CAM	Breast cancer

CAMs in bold, have been identified on tumor cells (for references see text and table 1). *Leukocytes act as a bridge between tumor cell and the endothelium