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. 2019 Jan 17;19:13. doi: 10.1186/s12911-018-0728-1

Table 4.

Longitudinal functions used in the JM

# Model NTXi(t)
Omit 1 Rational (β0+b0i)+(β1+b1i)1(t+δ)η+εi(t),δ>0,η>0
2 Exponential (β0+b0i) + (β1+b1i)exp(−δt)+εi(t), δ>0
3 Spline (β0+b0i) + NC (t,2, (β1,β2,β3)T, (b1i,b2i,b3i)T) + εi(t)
LOCF 4 Rational (β0+b0i)+(β1+b1i)1(t+δ)η+εi(t),δ>0,η>0
5 Exponential (β0+b0i) + (β1+b1i)exp(−δt)+εi(t), δ>0
6 Spline (β0+b0i) + NC(t,2, (β1,β2,β3)T, (b1i,b2i,b3i)T) + εi(t)
OCS 7 Rational (β0+b0i)+(β1+b1i)1(t+δ)η+εi(t),δ>0,η>0
8 Exponential (β0+b0i) + (β1+b1i)exp(−δt)+εi(t), δ>0
9 Spline (β0 + b0i) + NC(t,2,(β1,β2,β3)T, (b1i,b2i,b3i)T) + εi(t)