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. 2019 Jan 18;11:1. doi: 10.1186/s13099-018-0281-6

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Shift microbiota and diversity in gut microbiota of healthy controls, NBNC-HCC and B-HCC patients. a Venn diagram of OTUs in three groups. b Observed species numbers in three groups. c Rarefaction curve for the comparison of OTUs in three groups. d, e Comparison of the alpha diversity (ACE and CHAO1) based on the OTUs profiles. f Principal Co-ordinates Analysis (PCoA) of bacterial beta diversity based on the unweighted UniFrac distances. Each node represents each sample. Control, NBNC-HCC and B-HCC subjects are colored in red, green and blue, respectively. g–i Relative abundance of the top 10 microbiota at the phylum, order and genus level