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. 2019 Jan 17;11:8. doi: 10.1186/s13195-018-0463-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Boxplots for cerebrospinal fluid (CSF) levels in each sample of the three participating Euro-SCD centers. Values are presented in pg/ml. Points mark individual values lying outside 1.5 times the interquartile range (25–75% percentile). Asterisks mark extreme values lying outside three times the interquartile range. ^#The DELCODE and IDIBAPS sample show significantly lower levels compared with the ADC sample (p < 0.001). ADC Amsterdam Dementia Cohort, DELCODE German Center for Neurodegenerative Diseases (DZNE) multicenter Longitudinal Cognitive Impairment and Dementia Study, IDIBAPS l’Institut d’Investigacions Biomèdiques August Pi i Sunyer Hospital Clinic Barcelona