Fig. 2.

Cartoons of validated Notch repressors. Notch repressor proteins characterized in Drosophila and mammals are shown to scale. Protein size is given in amino acids (aa). a) Drosophila melanogaster. Upper panel displays H protein structure with the Su(H) interacting NT box (NT), the Groucho binding domain (GBD) and the C-terminal binding protein binding domain (CBD). Split ends protein (Spen, center panel) and Spenito (Nito, lower panel) contain four RNA recognition motifs (RRM) at the N-terminus, and a Spen paralog and ortholog C-terminal (SPOC) domain. b) Homo sapiens. SHARP protein belongs to the Spen protein family; it contains in addition to the RRM and the SPOC domain also a receptor interacting domain (RID), and the RBPJ interacting domain (RBP-ID). c) Mus musculus. KyoT2 is characterized by two complete LIM domains and the CSL interacting domain (CID)

d) Homo sapiens. RITA protein contains a central RBP interacting domain (RPB-ID) and a Tubulin binding motif at the C-terminus