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SNP-ChIP analysis of a protein modification. a γ-H2AX levels for the Red1 dosage strain series and a spo11-Y135F mutant relative to wild type produced by SNP-ChIP. b Fragment pileup produced using MACS2 with SPMR (fragment pileup per million reads) sequencing depth normalization on an example chromosome after spike-in normalization. c Detail of data in (b) showing a zoom-in on the left subtelomeric region
