Figure 3.
Atorvastatin regulated myocardial fibrosis via IL-6/ET-1. The secretion of ET-1 (A) and IL-6 (B) in plasma of the different groups. (C) IL-6 and ET-1 in myocardial tissue were detected via Western blot. *** P<0.001 vs. WKY. # P<0.05, ## P<0.01, ### P<0.001 vs. SHR. WKY – control group; SHR – SHR model group; Ato – Atorvastatin with 10, 25, 50 mg/kg per day; Ato+Ag490 – AG490 as a STAT3 inhibitor co-treated with Atorvastatin in SHR.
