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. 2019 Jan 8;12:327. doi: 10.3389/fnbeh.2018.00327

Figure 1.

Figure 1

Effects of dual orexin receptor antagonist-22 (DORA-22), triazolam, and eszopiclone on sleep time and sleep architecture. Time slept per every 30 min is shown for (A) DORA-22, (B) triazolam, and (C) eszopiclone for 6 h after p.o. administration of the drugs. The same values for the vehicle are shown repeatedly for comparison purposes. Each animal received DORA, triazolam, eszopiclone, and vehicle in a randomized order on spaced days. Data are shown as Mean ± SEM. (D) Comparison among the four treatments (F(3,12) = 5.101, p = 0.017) revealed that DORA-22 and triazolam, but not eszopiclone, significantly increased total sleep time during a 3-h period starting at 1 h after administration. These drugs did not affect sleep episode duration (F(3,12) = 0.906, p = 0.467; E) but did decrease awake episode duration (F(3,12) = 33.0, p < 0.001; F). In (D–F), data from the same animal are connected with lines to show possible interactions between drugs in individual mice. Horizontal lines indicate mean value for each treatment. Statistical results using repeated measure ANOVA followed by Tukey’s multiple comparisons test are indicated in the graph.