Table 2.
Genes differentially expressed between avian mucus (chicken and turkey) and mammalian mucus (cow, pig, and sheep).
| Gene | Fold change | Description | |
|---|---|---|---|
| GENES INCREASED IN C. jejuni GROWN IN AVIAN MUCUS RELATIVE TO MAMMALIAN MUCUS | |||
| Iron uptake systems | ceuB | −15 | Iron compound ABC uptake transporter permease protein |
| ceuC | −19 | enterochelin uptake permease | |
| ceuD | −8 | enterochelin uptake ATP-binding protein | |
| ceuE | −5 | Enterochelin uptake periplasmic binding protein | |
| cfbpA | −19 | Ferric iron ABC transporter, iron-binding protein | |
| cfbpB | −11 | Ferric iron ABC transporter, permease protein | |
| cfbpC | −8 | Putative iron-uptake ABC transport system ATP-binding | |
| cfrA | −89 | Ferric receptor CfrA | |
| chuA | −87 | Haemin uptake system outer membrane receptor | |
| chuB | −84 | Haemin uptake system permease protein | |
| chuC | −159 | Haemin uptake system ATP-binding protein | |
| chuD | −93 | Haemin uptake, periplasmic haemin-binding protein | |
| Cj0177 | −136 | iron transport protein | |
| Cj0178 | −74 | Putative outer membrane siderophore receptor | |
| Cj0241c | −9 | Hemerythrin domain protein | |
| Cj0818 | −51 | lipoprotein | |
| Cj0819 | −68 | Small hydrophobic protein | |
| Cj1383c | −179 | hypothetical protein, co expressed with haemin uptake | |
| Cj1384c | −92 | hypothetical protein, co expressed with haemin uptake | |
| Cj1397 | −20 | Ferrous iron transport protein A, putative | |
| Cj1587c | −7 | ABC-type siderophore export system | |
| Cj1613c | −17 | Putative heme oxygenase | |
| Cj1658 | −14 | High-affinity Fe2+/Pb2+ permease precursor | |
| Cj1660 | −14 | Fe2+ ABC transporter, substrate binding protein | |
| Cj1661 | −15 | Fe2+ ABC transporter, permease protein 1 | |
| Cj1662 | −14 | Fe2+ ABC transporter, permease protein 2 | |
| Cj1663 | −11 | Fe2+ ABC transporter, ATP-binding subunit | |
| exbB1 | −89 | Ferric siderophore transport system | |
| exbB2 | −24 | Ferric siderophore transport system | |
| exbD1 | −134 | Ferric siderophore transport system | |
| exbD2 | −80 | Biopolymer transport protein ExbD/TolR | |
| p19 | −17 | Periplasmic protein, high-affinity Fe2+ transport | |
| tonB1 | −19 | Ferric siderophore transport system, periplasmic binding | |
| tonB2 | −25 | Ferric siderophore transport system, periplasmic binding | |
| tonB3 | −11 | Ferric siderophore transport system, periplasmic binding | |
| Oxidative stress response | perR | −11 | Peroxide stress regulator |
| trxB | −7 | Thioredoxin reductase | |
| katA | −117 | Catalase | |
| Cj1386 | −44 | Ankyrin-repeat containing protein | |
| Cj1308 | −5 | Putative acyl carrier protein | |
| Cj0556 | −5 | 2-pyrone-4,6-dicarboxylic acid hydrolase | |
| Cj0379c | −8 | Probable sulfite oxidase | |
| bioC | −4 | O-methyltransferase | |
| ahpC | −11 | Alkyl hydroperoxide reductase subunit C | |
| acpP2 | −8 | Putative acyl carrier protein | |
| Membrane associated | Cj1668c | −5 | Putative periplasmic protein |
| Cj1665 | −10 | Possible lipoprotein thiredoxin | |
| Cj1664 | −13 | Possible periplasmic thiredoxin | |
| Cj1621 | −5 | Putative periplasmic protein | |
| Cj1406c | −6 | Putative periplasmic protein | |
| Cj1381 | −7 | putative lipoprotein | |
| Cj1376 | −15 | periplasmic protein | |
| Cj1372 | −5 | Phospholipid ABC transporter protein | |
| Cj1207c | −4 | Putative lipoprotein thiredoxin | |
| Cj1021c | −5 | Putative periplasmic protein | |
| Cj0926 | −6 | Membrane protein | |
| Cj0378c | −9 | Membrane protein | |
| Cj0176c | −15 | Lipoprotein | |
| Other functions | cetB | −5 | Signal transduction protein, energy taxis |
| Cj0120 | −5 | recombination protein RecO | |
| Cj0422c | −6 | H-T-H containing protein | |
| Cj0444 | −13 | pseudo gene | |
| Cj0459c | −11 | hypothetical protein | |
| Cj0717 | −8 | Glutathione-dependent thiol reductase | |
| Cj0878 | −4 | hypothetical protein | |
| Cj0880c | −5 | hypothetical protein | |
| Cj0963 | −5 | DNA polymerase, bacteriophage-type | |
| Cj1208 | −5 | 5-formyltetrahydrofolate cyclo-ligase | |
| dba | −14 | disulfide bond formation protein | |
| dnaN | −8 | DNA polymerase III beta subunit | |
| cgb | −5 | Bacterial hemoglobin, nitrosative stress | |
| GENES INCREASED IN C. jejuni GROWN IN MAMMALIAN MUCUS RELATIVE TO AVIAN MUCUS | |||
| fdxA | 14 | 4Fe-4S ferredoxin, iron-sulfur binding | |
| rrc | 14 | Rubrerythrin, oxidative stress tolerance | |
Differences are considered significant for genes that are differentially expressed greater than 4-fold with a FDR corrected P value less than 0.01. Genes with a negative fold change are increased in C. jejuni grown in the avian mucus, while positive fold change is increased in the mammalian mucus. Broad functional categories of differentially expressed genes are indicated to the right of genes.