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. 2019 Jan 11;9:3099. doi: 10.3389/fimmu.2018.03099

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Copyright © 2019 Hu, Gong, Gu, Geng, Li, Tian, Yang, Zhang, Shao, Liu, Wan, Jia, Yang, Shi and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The plasma miRNAs panel for AOSD diagnosis in a validation set. Expression levels of (A) miR-142-5p, (B) miR-101-3p, (C) miR-29c-3p, (D) miR-29a-3p, (E) miR-141-3p were analyzed by qRT-PCR in plasma from AOSD (N = 32) and HCs (N = 19). The results of histograms represent the means ± SD, ^*P < 0.05, ^****P < 0.0001. (F-H) ROC analysis for individual miRNAs and combined miRNA panel was analyzed by KNN (F), SVM (G), and LR (H) analysis. Logistic regression demonstrated that a linear combination of values for miR-142-5p, miR-101-3p, and miR-29a-3p produced the best model for AOSD diagnosis.